Ivermectin for humans
Ivermectin is a pill used to treat parasitic infestations, such as those caused by intestinal parasites in animals, and scabies in humans. Ivermectin is cheap and widely used in regions of the world where parasitic infestations are common. It has few undesirable and side effects. Ivermectin is included in the WHO’s Approximate List of Essential Medicines.
People are prescribed ivermectin only orally. The drug is rapidly absorbed, reaching a maximum concentration in plasma (about 50 mcg / l) 4 hours after taking a dose of 12 mg. It is widely distributed throughout the tissues (the volume of distribution is about 50 liters), but slowly and in a limited amount penetrates into the eye media. The half-life is 28 hours. It is excreted almost exclusively with feces.
Laboratory studies have shown that Ivermectin can slow down the reproduction of the COVID-19 virus (SARS-CoV-2), but such an effect on humans would require large doses. It should only be used in well-planned studies (called randomized controlled trials) evaluating potential effects.
The 2015 Nobel Prize in Physiology or Medicine was awarded for the discovery of Ivermectin and artemisinin. Ivermectin was discovered in 1975 and has been used in medicine since 1981
Sources: https://pubmed.ncbi.nlm.nih.gov/33592050 ; Sciencedirect.com
How does Ivermectin work?
Ivermectin – 22.23-dihydro is a derivative of natural avermectin B1, and consists of a mixture of equal homologues of 22.23-dehydro-B1a and B1b in a ratio of 80:20. The drug has a pronounced antiparasitic effect on larval and sexually mature stages of nematodes of the gastrointestinal tract and lungs, larvae of subcutaneous, nasopharyngeal and gastric gadflies, lice, bloodsuckers and sarcoptoid mites.
The mechanism of action of Ivermectin has been described in detail by many researchers. In nematodes, it stimulates the release of gamma-aminobutyric acid (GABA) by nerve endings and enhances its binding to postsynaptic GABA receptors, blocking the transmission of nerve impulses, which leads to paralysis and subsequent death of helminths.
Numerous studies have shown that Ivermectin invitro has a broad-spectrum antiviral activity. Initially identified as an inhibitor of the interaction between the integrase protein (IN) of the human immunodeficiency virus-1 (HIV-1) and the importin heterodimer (IMP) α/β1 responsible for nuclear import IN, Ivermectin has since been confirmed to inhibit nuclear import IN and HIV replication.
Ivermectin has been shown to inhibit nuclear import, including viral proteins, including the large tumor antigen of the monkey virus SV40 (T-ag) and non-structural protein 5 of the dengue virus. A number of studies have demonstrated the limitation of infection with RNA viruses, such as DENV 1-4, West Nile virus, influenza virus.
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Ivermectin can be classified as a highly effective drug on the US market. It also has an attractive price. Ivermectin can be used to cure almost any diseases associated with parasites and can cope with almost all types of so-called roundworms.
At the same time, it is necessary to get rid of the disease with the help of it carefully, since its main component is very active. Use without consultation is undesirable.
Indications for use
- demodecosis;
- miasma;
- scabies;
- pediculosis;
- trichocephalosis;
- filariasis;
- onchocerciasis;
- strongyloidosis;
- larva migrans.
Ivermectin for humans over the counter
Ivermectin disrupts the transmission of nerve impulses of parasites, which leads them to paralysis and death. A broad-spectrum antiparasitic drug, the tablets are highly effective against roundworms, but do not destroy tapeworms and flukes. Ivermectin is also used for scabies and pediculosis for people with unabated immunity. Despite the wide spectrum of action, the toxicity of the drug is relatively low when the dosage is observed.
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Nevertheless, the information provided on the website should not be regarded as a substitute for professional medical appointment. Please refrain from using this information for self-diagnosis or treatment without additional consultation with your doctor.
How to use Ivermectin?
- The drug ivermectin is produced in tablets, 10 pieces per pack. The original instructions for use for humans state that ivermectin is effective in fighting helminths in the human body.
- The patient should take the medicine orally on an empty stomach, washed down with plenty of water. The Daily Dose is taken at the rate of 15-20 mg/kg of human body weight.
- For a person, it is enough to take 1 or 2 doses of the drug, that is, 12 mg per day.
- After such therapy, the patient’s general condition will improve, but it is necessary to repeat taking ivermectin after 14 days.
The course of treatment should be monitored by a specialist, as it is necessary to pass certain tests in order to accurately understand the patient’s condition. The required dose of the drug can only be regulated by a doctor.
Interaction of Ivermectin with other medications
- The drug increases gabaergic activity. In this regard, it is not necessary to take Ivermectin simultaneously with other drugs that have similar effects. First of all, these are valproic acid, benzodiazepines and barbiturates.
- When Ivermectin is combined with other inhibitors, the risk of overcoming the blood-brain barrier increases. This is fraught with the development of serious side effects.
Storage conditions and shelf life
Shelf life 2 years. Store in a darkened place at a temperature of +2 to +30 degrees (86 degrees F). Do not leave small children unattended in plain sight.
Ivermectin for COVID-19
Official information on the use of Ivermectin at the link: COVID-19 Treatment Guidelines
Scheme of the proposed antiviral effect of Ivermectin on coronavirus.
IMPa/β1 binds to the coronavirus cargo protein in the cytoplasm (above) and moves it through the nuclear pore complex (NPC) to the nucleus where the complex decays, and the viral load can reduce the antiviral response of the host cell, which will lead to increased infection. Ivermectin binds and destabilizes the Impa/β1 heterodimer prevents Impa/β1 binding to the viral protein (below) and prevents it from entering the nucleus.
This is likely to lead to a reduction in the inhibition of antiviral reactions, resulting in a normal, more effective antiviral response.
Treatment of people with COVID-19 in the hospital
28 days after treatment with ivermectin when compared with placebo or conventional treatment, we do not know:
- does ivermectin lead to more or fewer deaths (2 studies, 185 people);
- does ivermectin worsen or improve the condition of patients assessed by the need for artificial ventilation (2 studies, 185 people) or oxygen (1 study, 45 people);
- increases or decreases the number of undesirable events (1 study, 152 people).
Seven days after treatment, we don’t know:
- increases or decreases ivermectin the number of negative tests for COVID-19 (2 studies, 159 people).
Compared with placebo or conventional treatment, Ivermectin may have little or no effect on improving the condition of patients 28 days after treatment (1 study, 73 people) or on the duration of hospital stay (1 study, 45 people).
Treatment of outpatient patients with COVID-19
Compared to placebo or conventional treatment, we don’t know:
- does ivermectin lead to more or fewer deaths 28 days after treatment (2 studies, 422 people);
- ivermectin worsens or improves the condition of patients 14 days after treatment, assessed by the need for artificial lung ventilation (1 study, 398 people);
- increases or decreases ivermectin the number of negative tests for COVID-19 seven days after treatment (1 study, 24 people).
Compared with placebo or conventional treatment, Ivermectin may have little or no effect on improving the condition of outpatient patients 14 days after treatment (1 study, 398 people) or on the number of adverse events 28 days after treatment (2 studies, 422 people).
- None of the studies examined the hospitalization of outpatient patients.
Prevention of COVID-19
We do not know whether ivermectin leads to more or fewer deaths compared to the lack of prevention (taking ivermectin) (1 study, 304 people); no participant died 28 days after taking the drug. This study presented results on the development of COVID-19 symptoms (but not confirmed SARS-CoV-2 infection) and adverse events, but in such a way that we could not include these results in our analysis. This study did not study hospitalization cases.
What are the limitations of this evidence?
Our confidence in the evidence is very low, as we were able to include only 14 studies with a small number of participants and a small number of events, such as death or the need for artificial ventilation. The methods in different studies were different, and they did not report everything that interested us, for example, about the quality of life. The evidence is current as of May 26, 2021.
Ivermectin side effects
The side effect of Ivermectin is similar to the Masotti reaction. It is maximally manifested 2 days after taking the drug. This condition is characterized by the following symptoms:
- fever (may last up to several days);
- headache and dizziness;
- weakness;
- drowsiness;
- skin rashes;
- severe itching;
- diarrhea;
- tachycardia;
- joint and muscle pain;
- peripheral edema;
- swelling of the lymph nodes.
It is believed that these symptoms are not due to the toxicity of the drug, but to the mass death of microfilariae. This is also indicated by the fact that the severity of signs of overdose depends on the degree of infection of the skin with parasites.
In rare cases, there is a spot opacity of the cornea, swelling of the eyelids, keratitis, conjunctivitis, neuritis of the optic nerve. These symptoms may be related to the disease itself.
Overdose in humans occurs quite rarely.
Overdose
If the recommended dosages are exceeded, the following symptoms may occur:
- skin rashes;
- urticaria;
- headache;
- general malaise;
- violation of coordination;
- tingling in the hands and feet;
- stomach pain;
- nausea with vomiting;
- diarrhea;
- dizziness;
- difficulty breathing;
- swelling of the arms, legs, face, ankles.
There are no specific means of detoxification. In case of overdose, the victim needs to wash his stomach and choose a symptomatic treatment.
Contraindications for Ivermectin
Do not use the drug in the following cases:
- allergic diseases or predisposition to them;
- weakened immunity;
- taking dietary supplements and herbs;
- asthma;
- meningitis;
- renal and/or hepatic insufficiency;
- children under 5 years of age.
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